What Should I Know About Mao-Inhibitors?
Some plants are considered plants of the gods, for their powers are laid to supernatural forces residing in their tissues, and they were Divine gifts to the earliest peoples of the Earth. Thousands of indigenous people use them in sacred religious and healing ceremonies, as part of their traditional religions.
Paganum Harmala and Banisteriopsis caapi are two such plants. These plants both contain an indole based alkaloid called Telepathine or Harmine that acts as a reversible MAO-A inhibitor.
Monoamine oxidase inhibitors (MAOIs) are class of drugs that inhibit the activity of one or both monoamine oxidase enzymes: monoamine oxidase A (MAO-A) and monoamine oxidase B (MAO-B). They have a long history of use as medications prescribed for the treatment of depression.
MAOI’s or MAO-inhibitors interfere with the action of the MAO enzyme and stop the breakdown of chemical compounds such as THC9, making it extremely effective when ingested orally. The term Cannhuasca is often used for any plant combination consisting of a Cannabinoids containing plant (Cannabis is the only plant known so far) and an MAOI. MAOI’s must be used with great caution because otherwise they can turn otherwise harmless foods into poisonous substances. The results can be dangerous: headaches, nausea, high blood pressure, even unconsciousness and death. Therefore, in shamanic traditions a special diet or fasting is observed in the days or hours before Cannhuasca is ingested. It is advisable to follow this tradition.
- Syrian rue / Peganum harmala)
- Banisteriopsis caapi
- Passionflower (weak)
- Yohimbe (weak)
Below is a list of substances that you should NOT take 12 hours before and 12 hours after taking a strong MAO-inhibitor as they are likely to cause Tyramine poisoning, resulting in Serotonin Poisoning.
- Antidepressants containing Selective Serotonine Reuptake Inhibitors (SSRI’s) such as the herb Kanna (Sceletium tortuosum) and pills such as paroxetine (Seroxat), fluoxetine (Prozac), citalopram (Cipramil), fluvoxamine (Fevarin) and sertraline (Zoloft)
- migraine medicines
- allergy medicines
- over the counter cough medicines
- amphetamines (speed)
- MDMA (XTC)
- mescaline cacti (peyote and san pedro)
May cause headaches or sickness:
Below is a list of substances and foods which are not dangerous, but are likely to cause headaches and/or Tyramine sickness
- Cultured dairy products (buttermilk, yogurt, and sour cream)
- all aged/mature cheese (exception: cottage cheese, cream cheese)
- dry and fermented sausage (bologna, salami, pepperoni, corned beef, and liver)
- all meat, fish and eggs which are not fresh
- pickled herring and salted dried fish
- meat extracts
- yeast extracts/brewer’s yeast (Marmite)
- fruits (bananas, avocados, canned figs, raisins, red plums, pine-apple, raspberries)
- nuts (peanuts)
- broad beans and pods (lima, fava beans, lentils, snow peas, and soy beans)
- soy sauce
- LSA (morning glory and baby hawaiian woodrose seeds)
- MDA related herbs (nutmeg, sweet flag)
- caffeine (coffee, tea, cola, guarana, energy drinks)
- St. Johns wort
- nasal sprays (Vicks Sinex, Prevalin or Otrivin)
- other MAO-inhibitors.